Clinical Recommendations for Photodynamic Therapy in the Management of Oral Mucosal Lesions

Abstract

Photodynamic therapy (PDT) is an innovative treatment modality that utilizes light-activated photosensitizing agents for the targeted destruction of abnormal tissues, particularly in the management of oral mucosal lesions such as leukoplakia, erythroplakia, and early-stage oral squamous cell carcinoma. This minimally invasive approach offers significant advantages over traditional therapies, including reduced patient discomfort, quicker recovery times, and preservation of healthy tissue. The efficacy of PDT is influenced by various factors, including the choice of photosensitizer, light source, and treatment protocols. Recent studies have demonstrated PDT's effectiveness in reducing lesion size and promoting healing while minimizing the risk of malignant transformation. However, variability in treatment outcomes necessitates further standardization and research to optimize protocols for different lesions. Emerging technologies, such as fiber-optic delivery systems, are enhancing the versatility of PDT, potentially expanding its applications beyond oncology to other medical conditions. This study aims to provide clinical recommendations for implementing PDT in oral mucosal lesions, highlighting its role as a promising option in modern medicine.