Propulsion of Antifungal Effects of Citrullus Lanatus, Cinnamomum Verum, Murraya Koenigii on Candida Albicans- An Invitro Study
Main Article Content
Abstract
Background:
The most common fungal infection is candidiasis caused by Candida albicans. It is treated either topical/systemically by a therapeutic antifungal agent, which has adverse effects when used for a long duration. Hence plant-based alternatives can be used. Citrullus lanatus seeds, Cinnamomum verum, and Murraya koenigii are plant-based products that can be used as an alternative to treat oral candidiasis caused by Candida albicans.
Aim:
The aim of the study was to evaluate the minimal inhibitory concentration of Citrullus lanatus, Cinnamomum verum, and Murraya koenigii against Candida albicans
Objectives:
The study's primary objective was to evaluate the minimal inhibitory concentration and fungicidal concentration of Citrullus lanatus, Cinnamomum verum, and Murraya koenigii against Candida albicans. The secondary objective of the study was to evaluate the biosynthesis of gold, silver, and selenium nanoparticles using Citrullus lanatus on Candida albicans
Materials And Methods:
The study was carried out in two phases. In phase one the minimal inhibitory concentration and fungicidal concentration of Citrullus lanatus, Cinnamomum verum, and Murraya koenigii against Candida albicans were evaluated. In phase two evaluate the biosynthesis of gold, silver, and selenium nanoparticles using Citrullus lanatus on Candida albicans was done.
Results:
A combination of Citrullus lanatus, Murraya koenigii and Cinnamomum verum had a minimal inhibitory concentration of 14 mm against fluconazole. Minimal fungicidal concentration is effective from 10-3 where more organisms were killed. The biosynthesis of gold nanoparticles on Citrullus lanatus greatly affects candida albicans with a minimal fungicidal concentration from 10-3.
Conclusion:
The present study shows that the combination of Citrullus lanatus, Murraya koenigii and Cinnamomum verum in powder form have a good effect against candida albicans. The higher the concentration greater the zone of inhibition. Biosynthesis of gold nanoparticles in Citrullus lanatus have a great effect against C.albicans with a minimal inhibitory concentration at 90%(10-3).