Synthesis, Spectral Characterization and Biological Evaluation of Novel Substituted 2, 4-Dithiobiuretes with Benzothiazole Backbone

Abstract

Drugs containing heterocyclic compounds showed remarkable and noticeable drug effect: hence they create their own importance in medicinal, agricultural and drug sciences. A simple and efficient method has been developed for the synthesis of a series of novel 2,4-dithiobiuret derivatives. In this work, a new series of 2-(5-subtituted-2,4-dithiobiurete) benzothiazole derivatives have been prepared by the interaction 1:1 molar proportion of 1-(benzo[d]thiazol-2-yl)thiourea (I a) with substituted isothiocyanates (II a-g) in 60% acetone-ethanol medium and the reaction mixture refluxed on water bath, recrystallized the product by using ethanol. This method provides the rapid and easy access of the product in very good yield. The recrystallized products were characterized on the basis of elemental analysis, chemical characteristics and spectral data. Screening of antimicrobial and antioxidant activities of novel synthesized compounds.