Unveiling the Potential of SEDDS in Delivering Lipophilic Drugs: Formulating Lulucanzole and Posacunazole Nanoemulsions for Enhanced Therapeutic Impact

Abstract

This research paper focuses on the preparation and evaluation of Lulucanzole and Posacunazole nanoemulsions for potential pharmaceutical applications.The preparation process was methodical, including components of the aqueous phase (sodium metabisulfite and aqua bidestilate), the oil phase (oleic acid, lucanzol, and posacunazole), and an emulsifier combination (Tween 80 and PEG 400). Homogenization and sonication techniques were employed to create clear nanoemulsions.

A number of analyses were carried out to evaluate these nanoemulsions' stability and quality. A particle size analyzer (PSA) was used to measure the distribution of particle sizes. organoleptic tests were performed to evaluate visual aspects and clarity, pH measurements were recorded, viscosity was assessed using a Brookfield viscometer, and the type of nanoemulsion was determined using a water-soluble dye (methylene blue) test. Additionally, the nanoemulsions underwent cycling tests and centrifugation tests to assess their stability under various conditions.

The results indicated that all formulations exhibited clear appearance, were odorless, and had a weak yellow color. pH measurements remained within the skin-compatible range throughout the 8-week storage period. Viscosity increased over time, suggesting stability, while the cycling and centrifugation tests showed no phase separation. Particle size measurements demonstrated that higher concentrations of Lulucanzole and Posacunazole resulted in larger particle sizes, but all formulations maintained sizes within the specified nanoemulsion range.

Furthermore, observations from the methylene blue test confirmed that all formulations exhibited an oil-in-water (o/w) emulsion type.

In conclusion, the developed Lulucanzole and Posacunazole nanoemulsions showed promising characteristics in terms of stability, particle size distribution, pH maintenance, and emulsion type. These findings lay the groundwork for potential pharmaceutical applications and further research in drug delivery systems.