Immunological and Anti-inflammatory Properties of Nanoparticles: A Review

Abstract

The physicochemical characteristics of nanoparticles, including size, charge, hydrophobicity, and shape, dictate how they interact with different immune system components. The objective of creating nanoparticles is to directly target the immune system or evade the immune identification. However, determining their unintentional effects on the immune system and comprehending the mechanisms behind these unintentional effects are crucial to determine the safety profile of a nanoparticle. Although the literature has addressed the immunostimulatory qualities previously, the immunosuppressive and anti-inflammatory properties have received less attention. This review's objective is to close this gap. The present article discuss about targeted immunosuppression brought about by either immunosuppressive or anti-inflammatory medication delivery via nanoparticles or by nanoparticle engineering. Further the inherent unintentional immunosuppressive characteristics of nanoparticles will be discussed along with the potential advantages or disadvantages of such attributes