Formulation and Evalution of Verapamil Hydrochloride Loaded Aquasomal Sustained Release Tablets

Abstract

Verapamil Hydrochloride is the hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent used for the treatment of high blood pressure . Verapamil Hydrochloride was loaded in Aquasomes to enhance its stability and solubility. The Aquasomes were prepared by inorganic core preparation method. The Aquasomal suspension is subjected to Lyophilization. The Lyophilized powder was made in to blend and is subjected to Precompression parameters followed by preparation of sustained release tablets by using HPMC K4, PVP K30 , Chitosan and Eudragit L 100 as polymers by Direct Compression method. Post compression parameters were conducted for all prepared sustained release tablets. All the formulations showed the desired physicochemical properties as per the official limits. The drug release studies were conducted for all formulations using USP II, paddle type apparatus with pH 1.2 buffer , pH 6.8 phosphate buffer and pH 7.4 phosphate buffer within 12 hours. Among all formulations, a better drug release of 97.56 % was shown for F9 using Eudragit L 100 as polymer. Kinetic studies were conducted for Optimized formulation F9 for Drug release mechanism. The release kinetics of the Optimized formulation F9 indicated that the formulation followed zero order kinetics with R² = 0.981 indicating that the drug release depends upon its concentration.