In-Situ Nasal Gel Formulations and Their Pharmaceutical Evaluation for the Treatment of Allergic Rhinitis Containing Extracts of Tagetes Erecta Linn and Similax Zeylanica

Abstract

The goal of this study was to create a thermo-reversible in-situ gel for the treatment of allergic rhinitis (AR). The goal of this study was to create a mucoadhesive in-situ gel with decreased nasal mucocilliary clearance in order to increase the local impact of a polyherbal extract in the treatment of allergic rhinitis (AR). The extended residency of the drug formulation in the nasal cavity is critical for intranasal medication administration. Gelling temperature, gelling duration, viscosity, gel strength, pH, drug content, mucoadhesive strength, spread ability, and irritancy tests were performed on the produced formulations.
Methods: In this investigation, pluronic F8 (PF8)-based mucoadhesive in-situ nasal gels containing Tagetes erecta Linn and Similax zeylanica extracts with antioxidant and anti-inflammatory properties were employed. By combining pluronic F8, poly (ethylene glycol) (PEG400), and Xanthan gum with a tiny quantity of (hydroxypropyl methylcellulose) HPMC K4M and Carbopol 934, a polyherbal thermosensitive in-situ hydrogel was created and assessed. A total of 9 in-situ extract gels were created using a mix of HPMC K4M, Carbopol, xanthan gum, and PF8. All of the preparations were evaluated, and the gel formation technique chosen underwent the temperature transition from sol to hydrogel.
After being injected into the nasal cavity, the mucoadhesive gel transforms into a viscous hydrogel at body temperature, reducing nasal mucociliary clearance and extending the duration of action. The best and most effective nasal herbal gel is made by combining varying concentrations of HPMC K4M, carbopol, or xanthan gum with PF8 (10% w/v). The results of the assessment parameters show that the in-situ gel made with corbopol was of higher quality than HPMC K4M and xanthan gum.
Conclusion: Based on these findings, in-situ herbal nasal gels may be promising drug delivery vehicles for Tagetes erecta Linn and Similax zeylanica extracts to circumvent first-pass metabolism and hence boost bioavailability. The mucoadhesive in-situ gel system is a potential technique for intranasal administration of polyherbal extracts for the enhancement of allergic rhinitis therapeutic effects.