Assessing the Relationship between Ace and Nos3 Gene Polymorphism and Chronic Cerebrovascular Insufficiency

Abstract

Association between ACEI/D, NOS3 4a/4b, and NOS3 C/T 786 gene polymorphisms and chronic cerebrovascular insufficiency (CCVI) was investigated in this study. The aim was to establish the relationship between these gene polymorphisms and CCVI and to explore the gene-gene interaction associated with this pathology. A total of 110 individuals were comprehensively examined, including 68 patients with CCVI as the main group and 42 healthy individuals as the control group. Gene polymorphisms of ACEI/D, NOS3 4a/4b, and NOS3 C/T 786 were determined using the polymerase chain reaction (PCR) method. The study found a significant dominance of the D allele and D/D genotype of the ACE gene and the 4b allele and 4b/4b genotype in CCVI patients, especially in stages III and IV. The highest occurrence of stages III and IV CCVI was observed in carriers of the I/I and D/D genotypes in combination with 4b/4b.