Age Features of Chronic Cerebrovascular Insufficiency in Some forms of Dysplasia of Cerebral Arteries

Abstract

Background: The purpose of this study was to examine the age-related characteristics of chronic cerebrovascular insufficiency (CCVI) in patients with various forms of cerebral artery dysplasia, as well as to analyze gender differences. Methods: Sixty-one patients were examined, of whom 20 were young adults (mean age 32.1±2.0 years). The control group consisted of 41 middle-aged and elderly patients (mean age 57.7±0.74 years). The study used paraclinical diagnostic methods to evaluate neurological symptoms and determine the type of cerebral artery lesion based on age.

Results: Hemodynamically significant changes were more often observed in deformities such as vessel inflexion at an acute angle, rather than in hypo- or aplasias. Pathological deformity (PD) and stenosis were also frequently observed in combination, contributing to the development of CCVI of varying severity. Young adult patients were more likely to experience migraine-like headaches, particularly men, while motor disorders, limb numbness, and dizziness were common in middle-aged and elderly patients. In young patients, angiodysplasias in the form of hypo- or aplasias without PD in the internal carotid artery (ICA) were often asymptomatic and congenital. PDs of the ICA were observed in middle-aged and elderly patients with stages III and IV of CCVI, developing throughout their lives in the context of hypertension, atherosclerosis, and other vascular diseases.

Conclusions: The study reveals that age and gender play a significant role in the development and manifestation of CCVI in patients with cerebral artery dysplasia. The findings highlight the importance of proper diagnosis and management of CCVI based on the patient's age and gender.