Significance of the C-reactive protein and antimicrobial peptide LL-37 in the clinical course in psoriasis patients.

Abstract

The article presents clinical (PASI index), immunological (C-reactive protein, antimicrobial peptide LDL-37), and microbiological studies in 56 patients with psoriasis.  Microbiological studies of lesions in patients with psoriasis revealed high colonization of Staphylococcal flora by St.aureus - 64.3+2.5 CFU/cm2, exceeding the indicators of healthy individuals by 18.4 times (3.5+0.4 CFU/cm2).  (P<0.05). The study results showed that with an increase in the severity of the PASI index, an increase in the level of C-reactive protein and the antimicrobial peptide LL-37 in the blood serum is noted against the background of increased colonization of staphylococcus spp. on the skin in patients with psoriasis. A high level of S. aureus in lesions and a high level of the antimicrobial peptide LL-37 in patients with psoriasis can be considered a trigger factor, and an increase in the level of CRP in the blood serum of patients with psoriasis plays a key role as a marker of systemic inflammation due to the stimulation of the pro-inflammatory systems