Designing, Optimization and Characterization of Linagliptin Transferosomal Gel to Actively Target Type Ii Diabetes

Abstract

Transfer somes are especially optimized, designed in ultraflexible lipid molecular aggregates, which are diffuse through human skin. Transfersome is a one type of carrier system which is susceptible for transdermal drug delivery system. It also diffuses through the pores of stratum corneum, which are smaller than its size. Different chemicals are used in this formulation. Soya lecithin, Span 80, methanol are used in analytical grade. Various formulations (F-1 to F-8) of transfersomes was prepared and evaluated for vesicle size and entrapment efficiency. The vesicle size of all transfersomes found between 465.2 and 314.3 nm. According to result, entrapment efficiency was found between 66.35 to 79.76 %. Results showing that formulation (F4) having small vesicle size and higher the entrapment efficiency. Formulation (F4) categorized as designed formulation and incorporated into gel base (F4 1% Carbopol, F4 2% Carbopol and F4 3% Carbopol) and evaluated for Drug content, pH, Spreadability, Viscosity measurements and drug release study. Transfersomes gel released 81.71% in regulated manner in 12 hours. The designed Linagliptin show the ability to formed transfersomal gel overcome the barrier properties and increase the drug release.